Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics InitiativeArticle Published on 2022-11-032022-11-15 Journal: PLoS Genetics [Category] SARS, 변종, 진단, [키워드] analysis Analysis association chromosome Cohort controls country COVID-19 Deleterious disease expected Genetic genetics Genome-wide association study identify increase in initiative loci outcome outcomes Pathogenesis performed rare variant Result severe disease Support susceptibility the SARS-CoV-2 TLR7 Toll-like receptor variant whole-genome sequencing with COVID-19 [DOI] 10.1371/journal.pgen.1010367 PMC 바로가기
Nucleic acid-sensing toll-like receptors: Important players in Sjögren’s syndromeReview Published on 2022-10-312023-07-10 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] Autoimmunity COVID-19 nucleic acid-sensing TLRs Sjögren’s syndrome systemic lupus erythematosus. TLR7 TLR8 TLR9 [DOI] 10.3389/fimmu.2022.980400 PMC 바로가기 [Article Type] Review
Artificial Neural Network-Based Study Predicts GS-441524 as a Potential Inhibitor of SARS-CoV-2 Activator Protein Furin: a Polypharmacology ApproachArticle Published on 2022-10-012022-11-15 Journal: Applied biochemistry and biotechnology [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] activator ANN Antiviral antiviral drug antivirals artificial Bacterial Bacterial infection Cancer caused Compound COVID-19 diabetes DNA drug Drug repurposing ENhance FCGR1A FDA furin furin cleavage site Grazoprevir GS-441524 help human protein inhibit inhibiting inhibitor inhibitors LB-VS LDLR mammalian MK-5172 network pharmacology Neural Neurological disorders pandemic Patient PCK1 PNP polybasic Polypharmacology Potential researcher SARS-CoV-2 SB-VS searched SOM. substrate target the spike protein TLR7 turn Virtual screening virus virus [DOI] 10.1007/s12010-022-03928-2 PMC 바로가기
Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll-like receptors dictates pathophysiology of COVID-19 disease주로 전염증성 사이토카인, 사이토카인 수용체 및 톨 유사 수용체의 개별 유전적 다양성이 COVID-19 질병의 병태생리를 좌우합니다Review Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alter B cells chemokine chemokines Clinical outcome clinical outcomes coding gene coding genes condition coronavirus coronavirus disease Coronavirus disease-19 Coronavirus-2 COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity cytokine Cytokine storm Cytokines determine exacerbate Gene Expression genes encoding Genetic genetic variability Genetic variation Genetic variations Host IL10 IL17 IL4 IL6 IL7 immune immune response immune responses Immunity individual Infection Inflammation Innate interferons Monocytes Mutation natural killer cell Natural killer cells Neutrophils nucleotide pathophysiology Patient polymorphism proinflammatory cytokines receptors respiratory symptoms response SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe respiratory symptoms severity of COVID-19 Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility T cells the patient TLR TLR3 TLR7 TLR9 TLRs TNF Toll-like receptor Toll-like receptors Toll-like receptors. understanding variants of concern Variation viral infection viral infections VOCs [DOI] 10.1002/jmv.27849 PMC 바로가기 [Article Type] Review
Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19심각하거나 치명적인 COVID-19에 대한 숙주 유전자 변이 및 감수성의 임상적 의미Review Published on 2022-08-192022-09-11 Journal: Genome Medicine [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advanced age age allergy Asymptomatic disease clinical clinical implications Clinical management clinical picture Comorbidities convergence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical deficiency develop Effects expected Factor Genetic genetic finding genetic screening Genetic variant Genetic variation healthy individual heterogeneous Host host genetics human immune response IFN-I Immunity implication indicate Infectious disease interferon Male sex malignancies manifestation Mendelian disorder Mendelian disorders modulate pandemic pathogenic variant pathway Pathways Patient Pneumonia predisposition Prevalence rare variant Rare variants risk factor SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe manifestations of COVID-19 shown susceptibility susceptibility loci the interferon TLR7 virus X-linked [DOI] 10.1186/s13073-022-01100-3 PMC 바로가기 [Article Type] Review
Intranasal administration of a virus like particles-based vaccine induces neutralizing antibodies against SARS-CoV-2 and variants of concern입자 기반 백신과 같은 바이러스의 비강 투여는 SARS-CoV-2 및 우려되는 변이체에 대한 중화 항체를 유도합니다.Article Published on 2022-08-012022-09-11 Journal: Allergy [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] administration Aerosols antibody antibody response against candidate vaccine Cell clinical trial contagious COVID-19 displaying elicited epitope evaluated help helper cell IgA antibodies IgA antibody immune response immunogenicity induce intranasal ligands local immune response lung tissue maintain Mask Masks mucosal mucosal immune murine model neutralize neutralizing antibody plasma Plasma cell platform Protective RBD RBD of SARS-CoV-2 recognize reduce required respiratory respiratory droplet Respiratory droplets SARS-CoV-2 Seven systemic and local T helper cell TLR7 TLR7/8 Transmission transmitted tropism tropism of SARS-CoV-2 Vaccine vaccine platform Vaccines variants of concern Viral viral shedding virus Virus-like particle virus-like particles virus-like particles. VLPs VOCs [DOI] 10.1111/all.15311 PMC 바로가기 [Article Type] Article
Host genetic basis of COVID-19: from methodologies to genesCOVID-19의 숙주 유전적 기반: 방법론에서 유전자까지Review Published on 2022-08-012022-09-11 Journal: European Journal of Human Genetics [Category] COVID19(2023년), SARS, 바이오마커, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 age association burden Burden test caused CFTR clinical manifestation Clinical outcome Comorbidities condition Coronavirus-2 COVID-19 COVID-19 Host Genetics Initiative COVID-19 pandemic COVID-19 patient COVID-19 patients described diagnostics disease severity explain Genetic genetic marker genome-wide significant genomic genomic loci GWAS help Initially initiative International loci methodology Predictive model provided public health rare variant SARS-CoV-2 SARS-COV-2 infection SELP Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Sex susceptibility the disease Therapeutics TLR3 TLR7 TMPRSS2 treating COVID-19 vaccination [DOI] 10.1038/s41431-022-01121-x PMC 바로가기 [Article Type] Review
Adjuvant-Protein Conjugate Vaccine with Built-In TLR7 Agonist on S1 Induces Potent Immunity against SARS-CoV-2 and Variants of ConcernS1에 TLR7 작용제가 내장된 아주반트-단백질 접합 백신은 SARS-CoV-2 및 우려 변종에 대한 강력한 면역을 유도합니다Article Published on 2022-07-082022-09-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] adjuvant adjuvant-protein conjugate agonist Alpha Antigen B.1.1.529 Beta cellular immunity Cluster concern conjugate Conjugates coronavirus disease COVID-19 disease Diseases Effect effective expected facilitate global pandemic humoral immune immune response induce mice Neutralizing antibodies neutralizing antibody New coronavirus omicron potent Prevent Protein recombinant protein vaccine. Research S1 protein S1 subunit Safe SARS-CoV-2 SARS-CoV-2 spike protein Spike protein the vaccine TLR7 TLR7 agonist Toxicity triggered Vaccine vaccine candidate variants of concern [DOI] 10.1021/acsinfecdis.2c00259 PMC 바로가기 [Article Type] Article
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine나노입자 전달 TLR4 및 RIG-I 작용제는 SARS-CoV-2 소단위 백신에 대한 면역 반응을 향상시킵니다Article Published on 2022-07-012022-09-11 Journal: Journal of controlled release : official journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] activated Adaptive immune response adjuvant adjuvants agonist Anti-spike anti-Spike IgG Antibody titer Antibody titers Antigen antigen-presenting cell antigen-presenting cells APC APCS B cell B cells BAL Bcl6 Blood bronchoalveolar CD4 CD44 Cell cell population characterized Combination adjuvant COVID-19 COVID-19 protein subunit vaccine CpG DLNs draining lymph node draining lymph nodes Efficacy ENhance follicular Germinal center GL7 helper cell humoral immune responses IgA IgG immune immune response immune responses Immunity IMPROVE in vitro in vivo Increases increases in Infection intramuscular intramuscular vaccination intranasal Intranasal versus intramuscular vaccination intranasally lead lung Lungs lymphocyte memory T memory T cell mice molecular Monophosphoryl lipid A MPLA Native neutralizing antibody titers Pattern recognition pattern recognition receptor Pattern recognition receptors Polymer Population Proinflammatory cytokine Protein subunit protein subunit vaccine Protein subunit vaccines PRR PRRs PUUC reaction receptor receptors responses against retinoic acid retinoic acid-inducible gene I RIG-I robust S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 spike protein. secretion spike IgA Spike protein stabilized spike protein stimulate subunit Subunit vaccine T cell T cell proliferation the S1 subunit TLR TLR4 TLR7 TLR7/8 TLR9 TLRs Toll-like receptor Toll-like receptors Transmission unique Vaccine vaccine availability vaccine responses variants [DOI] 10.1016/j.jconrel.2022.05.023 PMC 바로가기 [Article Type] Article